Name | Btk inhibitor 1 |
Synonyms | Btk inhibitor 1 |
CAS | 1412418-47-3 |
Molecular Formula | C22H22N6O |
Molar Mass | 386.4497 |
Solubility | 10 mM in DMSO |
Storage Condition | -20℃ |
Use | (Rac)-IBT6A is the racemate of IBT6A. IBT6A is an impurity of Ibrutinib. IBT6A can be used to synthesize IBT6A-Ibrutinib dimer and IBT6A adduct. Ibrutinib is an irreversible selective Btk inhibitor with an IC50 of 0.5 nM. |
Reference Show more | 1. Somana Siva Prasad, et al. A QUALITY BY DESIGN APPROACH FOR DEVELOPMENT OF SIMPLE AND ROBUST REVERSED PHASE STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF IBRUTINIB AND ITS IMPURITIES.2. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.3. Liu N, et al. Direct and two-step bioorthogonal probes for Bruton's tyrosine kinase based on ibrutinib: a comparative study. Org Biomol Chem. 2015 May 14;13(18):5147-57. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.588 ml | 12.938 ml | 25.877 ml |
5 mM | 0.518 ml | 2.588 ml | 5.175 ml |
10 mM | 0.259 ml | 1.294 ml | 2.588 ml |
5 mM | 0.052 ml | 0.259 ml | 0.518 ml |